IBB vs VXUS: Performance, Holdings, Fees & Risk
IBB and VXUS are ETFs, but they can differ materially in exposure, yield, fees and risk. IBB is iShares Biotechnology ETF, while VXUS is Vanguard Total International Stock ETF. VXUS is broader by holdings count, with 8,821 positions versus 247 for IBB. IBB is more concentrated at the top, based on top-10 holdings weight. Current AlgovestIQ evidence has VXUS ahead on AIQ Score, 64 versus 57.
What is the main difference between IBB and VXUS?
IBB puts 87% of its assets in Biotechnology, while VXUS spreads across 11 sectors with none above 22%.
| Metric | IBB | VXUS |
|---|---|---|
| Fund | ||
| Expense ratio | 0.44% | 0.05% |
| Holdings | 247 | 8,821 |
| Top-10 concentration | 47.5% | 12.9% |
| Distribution yieldTrailing 12 months | 0.16% | 2.37% |
| Average volume | 1,638,365 | 5,266,735 |
| Performance | ||
| 1Y return | +39.4% | +11.7% |
| YTD return | +28.2% | +11% |
| 5Y annualized returnTotal return, distributions reinvested | +6.3% | +8.3% |
| Risk | ||
| Annualized volatility | 22.8% | 17.2% |
| Max drawdown (1Y) | -9.7% | -11.4% |
| Max drawdown (5Y)Total return, distributions reinvested | -35.7% | -28.9% |
| Beta | 0.80 | 1.12 |
| Sharpe ratio | 1.33 | 0.46 |
| Sortino ratio | 2.43 | 0.68 |
| AlgovestIQ | ||
| AIQ Score | 57/100 | 64/100 |
| AIQ Edge Score | 6/10 | 9/10 |
| Momentum | 79/100 | 46/100 |
| Risk Resilience | 56/100 | 83/100 |
AlgovestIQ AIQ Comparison
iShares Biotechnology ETF vs Vanguard Total International Stock ETF
VXUS leads
VXUS leads by 7 AIQ points, primarily on Risk Resilience and Value, but the lead has narrowed from 13 points over 30 sessions.
Competitive: 3 of 4 evidence groups support VXUS, its lead is narrowing, and its signal state is cleanly positive.
iShares Biotechnology ETF
Vanguard Total International Stock ETF
The Algovestiq AIQ Score currently favors VXUS over IBB, 64 versus 57 as of Oct 31, 2026. VXUS's advantage is driven primarily by stronger risk resilience and value, while IBB holds the stronger momentum profile. VXUS also shows the weaker technical structure relative to its 50-day moving average. 3 of 4 covered evidence groups favor VXUS today, and the comparison is rated Competitive on stability: the leader's advantage has been narrowing. VXUS lead: Weakening — the AIQ differential moved from 13 to 7 points over 30 sessions.
Compare iShares Biotechnology ETF and Vanguard Total International Stock ETF across performance, expense ratio, dividend yield, drawdown, volatility and the Algovestiq AIQ Score.
IBB vs VXUS: which fits what
Each row is settled by a single measure. Where the gap is too small to matter it reads Similar, and no row decides the comparison as a whole.
| If you want | IBB | VXUS | Fits |
|---|---|---|---|
| Lower costExpense ratio | 0.44% | 0.05% | VXUS |
| Broader diversificationNumber of holdings | 247 | 8,821 | VXUS |
| Lower concentrationWeight of the 10 largest holdings | 47.5% | 12.9% | VXUS |
| Higher incomeTrailing 12-month distribution yield | 0.16% | 2.37% | VXUS |
| Smaller drawdownsMax drawdown, 5 years | -35.7% | -28.9% | VXUS |
| Lower volatilityAnnualized volatility, 1 year | 22.8% | 17.2% | VXUS |
Similar means the gap is within 0.01 percentage points of expense ratio, 25% more holdings, 3 points of top-10 weight, 0.2 points of yield, 2 points of drawdown or 1 point of volatility. Past drawdowns and volatility describe the funds’ history, not their future.
Performance over time
Total return with distributions reinvested, from daily closes for both ETFs.
Total return comparison
Growth of $10,000, distributions reinvested
Split-adjusted closes; each distribution is reinvested at the close on its ex-dividend date. Taxes and trading costs are not modeled.
Compare IBB and VXUS against another ticker
Open a multi-ticker workspace without changing this focused pair page.
AIQ Factor Divergence
Where the two separate, on the four dimensions behind the AIQ Score. Bars read outward from a shared zero: further from the centre is a wider gap.
- Momentum79 vs 46IBB +33
- Risk Resilience56 vs 83VXUS +27
- Value37 vs 59VXUS +22
- Quality60 vs 76VXUS +16
3 of 4 evidence groups favor VXUS. VXUS’s edge is concentrated in risk resilience and value; IBB keeps a meaningful momentum edge.
What changed since the last close
Latest scored session 2026-10-28, compared against the prior scored session 2026-10-27.
Largest factor move: Momentum +7
New signals
- BB Upper Band Breach — bearish, volatility, short horizon
Largest factor move: Momentum +14
New signals
- MACD Bullish Crossover — bullish, momentum, short horizon
VXUS's lead widened by 2 AIQ points in the latest session.
Deeper signal detail for each name lives on its own signals page — IBB and VXUS both carry a full feed there.
The central trade-off
VXUS (Vanguard Total International Stock ETF): the stronger current systematic profile, led by risk resilience and value.
IBB (iShares Biotechnology ETF): the counter-case, on momentum, technicals — but at materially higher volatility, 28.5% against 11.6%.
Fund facts, side by side
Two funds tracking overlapping universes are separated by cost and risk far more than by holdings. Those lead here.
| Measure | IBB | VXUS | Why it matters |
|---|---|---|---|
| Expense ratio | 0.44% | 0.05% | Lower is better — it compounds against you every year you hold. |
| Holdings | 247 | 8,821 | More holdings means broader diversification, not better returns. |
| Average volume | 1,638,365 | 5,266,735 | Liquidity — matters most if you trade size. |
| Annualized volatility | 22.8% | 17.2% | Lower is a steadier ride for the same exposure. |
| Max drawdown (1Y) | -9.7% | -11.4% | The worst peak-to-trough loss over the past year. |
| Sharpe ratio | 1.33 | 0.46 | Return per unit of risk. Higher is better. |
| Beta | 0.80 | 1.12 | Sensitivity to the broad market. Neither direction is better — it depends on the role in your portfolio. |
Where the exposure actually sits
Sector exposure for each fund, ordered by the size of the difference.
How much of the same holdings they own
IBB and VXUS share 0.16% of their weighted exposure across 5 common holdings.
239 holdings are unique to IBB, and 8,276 holdings are unique to VXUS. Owning both is genuinely additive — most of the capital sits in different securities.
IBB is the more concentrated of the two: its ten largest positions are 47.53% of the fund, against 12.94% for VXUS (247 holdings vs 8,821). Concentration cuts both ways — it is what drives outperformance when the top names work, and what makes the drawdown deeper when they do not.
Largest shared positions
| Holding | IBB | VXUS | Shared |
|---|---|---|---|
| ARGXARGENX SE ADR | 3.8% | 0.12% | 0.12% |
| GMABGENMAB SPONSORED ADR | 1.26% | 0.04% | 0.04% |
| AURAAURA BIOSCIENCES | 0.03% | 0% | 0% |
| ABVXABIVAX AMERICAN DEPOSITARY SHARES | 0.56% | 0% | 0% |
| ALVOALVOTECH SA | 0.05% | 0% | 0% |
Shared weight is the lower of the two positions — the portion of capital both funds genuinely have in the same security.
What IBB adds that VXUS doesn’t
| Holding | IBB | VXUS |
|---|---|---|
| VRTXVERTEX PHARMACEUTICALS | 7.94% | Not held |
| AMGNAMGEN INC | 7.92% | Not held |
| GILDGILEAD SCIENCES | 7.38% | Not held |
| REGNREGENERON PHARMACEUTICALS | 5.95% | Not held |
| ARGXARGENX SE ADR | 3.8% | 0.12% |
| MRNAMODERNA | 3.6% | Not held |
What VXUS adds that IBB doesn’t
| Holding | VXUS | IBB |
|---|---|---|
| 2330.TWTaiwan Semiconductor Manufacturing Co Ltd | 4.02% | Not held |
| 005930.KSSamsung Electronics Co Ltd | 1.8% | Not held |
| ASML.ASASML Holding NV | 1.42% | Not held |
| 000660.KSSK hynix Inc | 1.41% | Not held |
| 0700.HKTencent Holdings Ltd | 0.85% | Not held |
| HSBA.LHSBC Holdings PLC | 0.82% | Not held |
Each list is a fund’s largest positions by weight that the other fund does not hold, or holds at less than half the weight.
IBB vs VXUS: five-year payout growth
VXUS grew its split-adjusted payout faster over 2020-2025 — 13.28% a year against IBB's 4.54%. IBB: The 2020 payout was 22.3% below 2019, so the growth rate measures a recovery from a weak starting year. VXUS: The 2020 payout was 24.6% below 2019, so the growth rate measures a recovery from a weak starting year. VXUS: The payout jumped 53.0% in 2021, a single step rather than steady compounding - often an index or mandate change. VXUS: A single payment in an endpoint year was 3.9x the fund's median payment, so one distribution carries much of the result.
| Dividend metric | IBB | VXUS |
|---|---|---|
| 5Y payout CAGR | 4.54% | 13.28% |
| 2020 annual payout | $0.310 | $1.286 |
| 2025 annual payout | $0.387 | $2.399 |
| Calendar-year declines | 2 | 1 |
| Peer rank | #101 of 138 | #43 of 138 |
Split-adjusted annual distributions, 2020–2025. Research as of Sep 19, 2026. Yield and expense ratio above are current values, not part of this window.
AIQ Agreement Matrix
3 of 4 covered evidence groups favor VXUS. A wide gap backed by one group is a weaker case than a narrow gap backed by five.
| Evidence group | Favors | Reading |
|---|---|---|
| AIQ Score | VXUS | 57 vs 64 |
| Fundamentals | Not covered | Not covered |
| Valuation | VXUS | Value 37 vs 59 |
| Technicals | IBB | Price vs 50-day 4.5% vs -3.9%; vs 200-day 17.4% vs 0.5% |
| Risk Resilience | VXUS | Risk Resilience 56 vs 83 |
| Analyst expectations | Not covered | Not covered |
✓ agrees with the overall verdict · ✕ points the other way. Groups marked “not covered” lack data on one or both of IBB and VXUS and are excluded from the count.
AIQ Decision Stability
The two are close enough that your objective, not the score, should decide.
- The AIQ gap is moderate at 7 points.
- The leader's advantage has been narrowing. (argues the conclusion is provisional)
- The leader's signal state is cleanly positive. (supports the conclusion holding)
Stability combines the score gap, how broadly the evidence agrees, how steady the lead has been across daily snapshots, the current signal state on both names, and analyst dispersion on VXUS.
How the comparison changed
120 daily snapshots · Jun 29 – Oct 28VXUS lead: Weakening — the AIQ differential moved from 13 to 7 points over 30 sessions.
- Today
- VXUS +7
- 57 vs 64
- 7 sessions ago
- VXUS +6
- 53 vs 59
- 30 sessions ago
- VXUS +13
- 49 vs 62
- 90 sessions ago
- VXUS +11
- 56 vs 67
The lead has not changed hands in this window.
AIQ Signal Divergence
Only the signals that bear on the head-to-head. A conflicted name is carrying bullish and bearish rules at the same time — the technical evidence is not pointing one way.
5 bullish / 1 bearish, conflicted
Only IBB
- BB Upper Band Breach — bearish, volatility, short horizon
- EMA Ribbon Expansion Bullish — bullish, trend, medium horizon
- 52-Week High Proximity — bullish, risk, long horizon (0.0%)
- Uptrend Structure Active — bullish, trend, long horizon
2 bullish / 0 bearish / 2 neutral
Only VXUS
- Bollinger Band Squeeze — neutral, volatility, short horizon
- ATR Contraction - Coiling — neutral, volatility, short horizon (1.03%)
Both carry 2 more signals that do not separate them: Golden Cross Active, MACD Bullish Crossover.
IBB is conflicted, so the timing case there is weaker than the score alone suggests.
Price vs model alignment
Whether the latest session's price move confirms what the model did over the same session, or contradicts it.
Price is down while the AIQ Score moved up 1 points over the same session — price and model disagree (price -0.11%, AIQ +1 points).
Price is down while the AIQ Score moved up 3 points over the same session — price and model disagree (price -1.53%, AIQ +3 points).
What would flip this result
A state, not a forecast. These are the specific, observable changes that would reverse the verdict — not a price prediction.
- 1IBB closes the Risk Resilience gap — currently 27 points behind, the largest single contributor to VXUS's edge.
- 2IBB's BB Upper Band Breach resolves — a bearish volatility rule currently active against it.
- 3VXUS's Golden Cross Active breaks down — it is the strongest rule currently supporting the verdict.
- 4The narrowing continues — the lead has already given back 6 points over 30 sessions, and a further 7-point move would eliminate VXUS's advantage entirely.
The full evidence
Every number behind the verdict. The leader is called above each group so you are not left to solve it from the table.
Performance
IBB leads 6 of 6 windows| Metric | IBB | VXUS |
|---|---|---|
| 1 week (5 sessions) | 2.3% | -0.3% |
| 1 month (20 sessions) | 2.8% | -1.4% |
| 3 months (63 sessions) | 13.9% | -1.2% |
| 6 months (126 sessions) | 30.8% | 3.1% |
| Year to date | 28.2% | 11% |
| 1 year (252 sessions) | 39.4% | 11.7% |
Technicals
IBB has the stronger structure| Metric | IBB | VXUS |
|---|---|---|
| RSI (14) | 66.8 | 47.3 |
| ADX (14) | 11.5 | 22.4 |
| Price vs 50-day | 4.5% | -3.9% |
| Price vs 200-day | 17.4% | 0.5% |
| Volatility (1M, annualized) | 28.5% | 11.6% |
Risk
VXUS is the more resilient| Metric | IBB | VXUS |
|---|---|---|
| Beta | 0.8 | 1.12 |
| Sharpe ratio | 1.33 | 0.46 |
| Sortino ratio | 2.43 | 0.68 |
| Max drawdown | -9.7% | -11.4% |
| Current drawdown | -0.3% | -5.3% |
| Annualized volatility | 22.8% | 17.2% |
| Value at risk (95%) | -2.2% | -1.7% |
Straight answers
Short answers to the questions fund investors ask about this pair, from the figures above.
What is the difference between IBB and VXUS?
IBB puts 87% of its assets in Biotechnology, while VXUS spreads across 11 sectors with none above 22%.
How much do IBB and VXUS overlap?
IBB and VXUS share 0.16% of their weighted exposure across 5 common holdings. 239 holdings are unique to IBB, and 8,276 holdings are unique to VXUS. Owning both is genuinely additive — most of the capital sits in different securities.
Which ETF is more diversified, IBB or VXUS?
VXUS holds more positions: 8,821 versus 247 for IBB.
Which has the lower expense ratio?
VXUS has the lower expense ratio, 0.05% a year against 0.44% for IBB.
Which ETF has the higher distribution yield?
VXUS, with a trailing 12-month distribution yield of 2.37% against 0.16% for IBB.
Which ETF has been more volatile?
IBB has been more volatile over the past year, at 22.8% annualized against 17.2% for VXUS.
Which ETF has had the smaller drawdown?
VXUS fell less from peak to trough over the past five years: -28.9% against -35.7% for IBB.
Compare IBB and VXUS with others
Continue your research
This page answers which of the two. These answer the questions on either side of it.
How this comparison is scored
The Algovestiq AIQ Score composites four factors — Quality, Value, Momentum and Risk, each carrying a fixed weight. Sentiment is reported separately as SentimentPulse and is not folded into the composite. Scores refresh every trading day, and this page regenerates from the latest snapshot rather than being written once.
The verdict names a leader, states how broadly six independent evidence groups agree, and rates how durable that conclusion is given the score gap, its recent trajectory and the current signal state on both names.
How to use side-by-side comparison →This comparison is informational and educational, not investment advice. AIQ scores update daily; re-check after earnings, guidance or macro data that materially changes either name’s factor profile.