ALGN vs KPTI Stock Comparison
Compare ALGN vs KPTI on performance, valuation, growth, fundamentals, momentum and risk; the current AIQ evidence does not show a clear headline leader.
What is the main difference between ALGN and KPTI?
ALGN and KPTI are close on the current AIQ evidence, so the better fit depends more on objective, risk tolerance and valuation preference than on a single headline score.
AlgovestIQ AIQ Comparison
Align Technology, Inc. vs Karyopharm Therapeutics Inc.
ALGN and KPTI are effectively level
ALGN and KPTI are effectively level on the AIQ Score; the factor table below shows where each one holds its advantage.
Align Technology, Inc.
Karyopharm Therapeutics Inc.
The Algovestiq AIQ Score does not currently separate ALGN and KPTI as of Oct 31, 2026. Both names are scored on the same 0–100 scale across Quality, Value, Momentum and Risk Resilience, and the factor table below shows where each one holds its advantage.
Compare Align Technology, Inc. and Karyopharm Therapeutics Inc. across the Algovestiq AIQ Score, valuation, quality, momentum, risk, technicals and analyst expectations.
Performance over time
Price return from daily closes; distributions are not included.
Price return comparison
Growth of $10,000, price only
Split-adjusted closes only. Distributions are excluded, which understates the return of any fund or stock that pays them.
Compare ALGN and KPTI against another ticker
Open a multi-ticker workspace without changing this focused pair page.
AIQ Factor Divergence
Where the two separate, on the four dimensions behind the AIQ Score. Bars read outward from a shared zero: further from the centre is a wider gap.
- Quality70 vs 100KPTI +30
- Risk Resilience58 vs 32ALGN +26
- Momentum76 vs 51ALGN +25
- Value62 vs 65Even
Neither name separates cleanly on the covered dimensions.
What changed since the last close
Latest scored session 2026-10-28, compared against the prior scored session 2026-10-27.
Largest factor move: Momentum -1
No signal started or stopped since the prior session; its 3 active signals are unchanged.
Largest factor move: Momentum +19
No signal started or stopped since the prior session; its 4 active signals are unchanged.
ALGN's lead narrowed by 6 AIQ points in the latest session.
Deeper signal detail for each name lives on its own signals page — ALGN and KPTI both carry a full feed there.
Which one fits your objective
The same two names rank differently depending on what you are optimizing for. All six reads are shown at once — none of them is hidden behind a toggle.
Balanced
EvenNeither separates on the overall score.
Growth
ALGNALGN on combined revenue and EPS growth.
Value
EvenThe two are level on Value.
Momentum
ALGNALGN on the Momentum factor, by 25 points.
Lower downside
ALGNALGN on Risk Resilience, by 26 points.
Analyst upside
KPTIKPTI on implied upside to the consensus price target.
AIQ vs Wall Street
Where the systematic read and the analyst consensus line up — and where they do not.
| Measure | ALGN | KPTI | Note |
|---|---|---|---|
| Implied upside to target | +28.4% | +1221.8% | KPTI has more room |
| Target dispersion | +27.5% | +148.6% | Lower is tighter analyst agreement |
| Consensus | Buy | Buy | Context, not a primary driver |
| Analysts covering | 6 | 3 | Higher coverage generally improves confidence |
Analyst targets are expectations, not predictions. Dispersion matters as much as the midpoint.
AIQ Agreement Matrix
How each independent group of evidence reads the pair.
| Evidence group | Favors | Reading |
|---|---|---|
| AIQ Score | Even | 67 vs 67 |
| Fundamentals | ALGNon balance | revenue growth 1.5% vs -4.7%; EPS growth -4.4% vs -127.5%; TTM ROE 10.1% vs 77.6%; gross margin 66.5% vs 95.9%; operating margin 13.3% vs -56.2% — ALGN takes 3 of 5 decided legs, not all of them |
| Valuation | Even | Value 62 vs 65 |
| Technicals | ALGN | Price vs 50-day -0.6% vs -47.8%; vs 200-day -9.1% vs -86.4% |
| Risk Resilience | ALGN | Risk Resilience 58 vs 32 |
| Analyst expectations | KPTI | Target upside 28.4% vs 1221.8% |
AIQ Decision Stability
The conclusion is sensitive to small changes. Treat the lead as provisional and watch the flip conditions below.
- The AIQ gap is narrow at 0 points. (argues the conclusion is provisional)
- Only 0 of 6 covered evidence groups agree. (argues the conclusion is provisional)
- The leader's advantage has been narrowing. (argues the conclusion is provisional)
- Analyst targets on the leader are widely dispersed. (argues the conclusion is provisional)
How the comparison changed
120 daily snapshots · Jun 29 – Oct 28KPTI lead: Weakening — the AIQ differential moved from 6 to 0 points over 30 sessions.
- Today
- Level
- 67 vs 67
- 7 sessions ago
- ALGN +5
- 68 vs 63
- 30 sessions ago
- KPTI +6
- 55 vs 61
- 90 sessions ago
- KPTI +11
- 54 vs 65
The lead changed hands 9 times in this window, most recently on Oct 19 when ALGN moved ahead of KPTI.
AIQ Signal Divergence
Only the signals that bear on the head-to-head. A conflicted name is carrying bullish and bearish rules at the same time — the technical evidence is not pointing one way.
1 bullish / 2 bearish, conflicted
Only ALGN
- RSI Overbought — bearish, momentum, short horizon
1 bullish / 2 bearish / 1 neutral, conflicted
Only KPTI
- ATR Expansion - Breakout Mode — neutral, volatility, short horizon (17.51%)
- Downtrend Structure Active — bearish, trend, long horizon
Both carry 2 more signals that do not separate them: Death Cross Active, MACD Bullish Crossover.
Price vs model alignment
Whether the latest session's price move confirms what the model did over the same session, or contradicts it.
Price and the AIQ Score both moved down over the latest session (price -2.49%, AIQ -1 points).
Price is down while the AIQ Score moved up 5 points over the same session — price and model disagree (price -24.76%, AIQ +5 points).
The full evidence
Every number behind the verdict. The leader is called above each group so you are not left to solve it from the table.
Fundamentals
ALGN leads on balance| Metric | ALGN | KPTI |
|---|---|---|
| Revenue growth (YoY) | 1.5% | -4.7% |
| EPS growth (YoY) | -4.4% | -127.5% |
| Gross margin | 66.5% | 95.9% |
| Operating margin | 13.3% | -56.2% |
| Return on equity (TTM) | 10.1% | 77.6% |
| Debt to equity | 0.03 | -0.65 |
Performance
ALGN leads 5 of 6 windows| Metric | ALGN | KPTI |
|---|---|---|
| 1 week (5 sessions) | 1.5% | 50.2% |
| 1 month (20 sessions) | 5.7% | -31.8% |
| 3 months (63 sessions) | -11.4% | -88.1% |
| 6 months (126 sessions) | -13.9% | -90.1% |
| Year to date | -1.6% | -88.7% |
| 1 year (252 sessions) | 13.6% | -86.9% |
Technicals
ALGN has the stronger structure| Metric | ALGN | KPTI |
|---|---|---|
| RSI (14) | 72.2 | 61.2 |
| ADX (14) | 24.1 | 54.3 |
| Price vs 50-day | -0.6% | -47.8% |
| Price vs 200-day | -9.1% | -86.4% |
| Volatility (1M, annualized) | 23.9% | — |
Risk
ALGN is the more resilient| Metric | ALGN | KPTI |
|---|---|---|
| Beta | 1.3 | 0.48 |
| Sharpe ratio | 0.46 | -0.5 |
| Sortino ratio | 0.79 | -0.59 |
| Max drawdown | -29.2% | -97% |
| Current drawdown | -22.2% | -92.2% |
| Annualized volatility | 39.3% | 148.2% |
| Value at risk (95%) | -3.6% | -10.3% |
Straight answers
Each answer is regenerated from the current snapshot, not written once and left to age.
Which has more analyst upside, ALGN or KPTI?
Analyst price targets imply +28.4% upside for ALGN and +1221.8% for KPTI, so the Street currently favors KPTI. Analyst targets are expectations, not predictions, and dispersion matters as much as the midpoint.
Which is better value, ALGN or KPTI?
Neither name separates on the peer-relative Value factor. The two are level on Value. The Value factor reads valuation relative to sector peers and to the company's own fundamental quality, so it is not the same as simply having the lower multiple.
Which has stronger growth, ALGN or KPTI?
ALGN on combined revenue and EPS growth. Growth here is measured on reported revenue and earnings, not on forward estimates — it describes what the businesses have delivered, not what the Street expects next.
Which has stronger momentum, ALGN or KPTI?
ALGN on the Momentum factor, by 25 points. Momentum is one of the four weighted factors in the AIQ composite. It has documented persistence over three- to twelve-month horizons, which makes it a timing input rather than a reason to hold something indefinitely.
Which is riskier, ALGN or KPTI?
ALGN is the more resilient of the two, so the other name carries the higher downside risk. ALGN on Risk Resilience, by 26 points. Risk Resilience is a weighted factor in the composite; position sizing usually responds to it more usefully than the buy/avoid decision does.
Is ALGN more profitable than KPTI?
The profitability evidence is mixed: gross margin 66.5% vs 95.9%; operating margin 13.3% vs -56.2%; ttm roe 10.1% vs 77.6%. ALGN leads on one measure and KPTI on two measures, and there is no single profitability composite that resolves the split — which of the two reads as "more profitable" depends on whether you weight pricing power or operating leverage.
What do the current signals say about ALGN and KPTI?
ALGN: 1 bullish / 2 bearish, conflicted. KPTI: 1 bullish / 2 bearish / 1 neutral, conflicted. A conflicted state means bullish and bearish rules are active on the same name at once — the technical evidence is not pointing one way, and a decision taken on it carries more timing risk. The most decision-relevant rule on ALGN is Death Cross Active (bearish, long horizon). On KPTI it is Death Cross Active (bearish, long horizon).
Compare ALGN and KPTI with others
Continue your research
This page answers which of the two. These answer the questions on either side of it.
How this comparison is scored
The Algovestiq AIQ Score composites four factors — Quality, Value, Momentum and Risk, each carrying a fixed weight. Sentiment is reported separately as SentimentPulse and is not folded into the composite. Scores refresh every trading day, and this page regenerates from the latest snapshot rather than being written once.
The verdict names a leader, states how broadly six independent evidence groups agree, and rates how durable that conclusion is given the score gap, its recent trajectory and the current signal state on both names.
How to use side-by-side comparison →This comparison is informational and educational, not investment advice. AIQ scores update daily; re-check after earnings, guidance or macro data that materially changes either name’s factor profile.