KPTI vs LEGN Stock Comparison
KPTI currently leads LEGN in this stock comparison, with AIQ scores of 61 vs 48. The clearest difference is quality, while LEGN has the stronger momentum profile.
What is the main difference between KPTI and LEGN?
KPTI leads the current stock comparison as Karyopharm Therapeutics Inc., with the clearest separation coming from quality and the broader AIQ evidence mix.
AlgovestIQ AIQ Comparison
Karyopharm Therapeutics Inc. vs Legend Biotech Corporation
KPTI leads
KPTI leads by 13 AIQ points, primarily on Quality and Value.
Fragile: 3 of 6 evidence groups support KPTI, and its current signal state is conflicted.
Karyopharm Therapeutics Inc.
Legend Biotech Corporation
The Algovestiq AIQ Score currently favors KPTI over LEGN, 61 versus 48 as of Oct 22, 2026. KPTI's advantage is driven primarily by stronger quality and value, while LEGN holds the stronger momentum profile. KPTI also shows the weaker technical structure relative to its 50-day moving average. 3 of 6 covered evidence groups favor KPTI today, and the comparison is rated Fragile on stability: only 3 of 6 covered evidence groups agree. KPTI lead: Stable — the AIQ differential has held near 13 points over 30 sessions.
Compare Karyopharm Therapeutics Inc. and Legend Biotech Corporation across the Algovestiq AIQ Score, valuation, quality, momentum, risk, technicals and analyst expectations.
Performance over time
Price return from daily closes; distributions are not included.
Price return comparison
Growth of $10,000, price only
Split-adjusted closes only. Distributions are excluded, which understates the return of any fund or stock that pays them.
Compare KPTI and LEGN against another ticker
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AIQ Factor Divergence
Where the two separate, on the four dimensions behind the AIQ Score. Bars read outward from a shared zero: further from the centre is a wider gap.
- Quality100 vs 52KPTI +48
- Momentum25 vs 38LEGN +13
- Risk Resilience32 vs 45LEGN +13
- Value65 vs 54KPTI +11
3 of 6 evidence groups favor KPTI. KPTI’s edge is concentrated in quality and value; LEGN keeps a meaningful momentum edge.
What changed since the last close
Latest scored session 2026-10-21, compared against the prior scored session 2026-10-20.
No factor moved materially.
No signal started or stopped since the prior session; its 7 active signals are unchanged.
Largest factor move: Momentum +1, not enough on its own to move the overall score.
No signal started or stopped since the prior session; its 5 active signals are unchanged.
KPTI's lead was unchanged in the latest session.
Deeper signal detail for each name lives on its own signals page — KPTI and LEGN both carry a full feed there.
The central trade-off
KPTI (Karyopharm Therapeutics Inc.): the stronger current systematic profile, led by quality and value.
LEGN (Legend Biotech Corporation): the counter-case, on momentum, risk resilience, fundamentals.
Which one fits your objective
The same two names rank differently depending on what you are optimizing for. All six reads are shown at once — none of them is hidden behind a toggle.
Balanced
KPTIKPTI on the overall AIQ Score, which weights Quality and Value most heavily.
Growth
LEGNLEGN on combined revenue and EPS growth.
Value
KPTIKPTI on the peer-relative Value factor, by 11 points.
Momentum
LEGNLEGN on the Momentum factor, by 13 points.
Lower downside
LEGNLEGN on Risk Resilience, by 13 points.
Analyst upside
KPTIKPTI on implied upside to the consensus price target.
AIQ vs Wall Street
Where the systematic read and the analyst consensus line up — and where they do not.
| Measure | KPTI | LEGN | Note |
|---|---|---|---|
| Implied upside to target | +1767.8% | +197.8% | KPTI has more room |
| Target dispersion | +127.5% | +88.8% | Lower is tighter analyst agreement |
| Consensus | Buy | Buy | Context, not a primary driver |
| Analysts covering | 4 | 7 | Higher coverage generally improves confidence |
Analyst targets are expectations, not predictions. Dispersion matters as much as the midpoint.
AIQ Agreement Matrix
3 of 6 covered evidence groups favor KPTI. A wide gap backed by one group is a weaker case than a narrow gap backed by five.
| Evidence group | Favors | Reading |
|---|---|---|
| AIQ Score | KPTI | 61 vs 48 |
| Fundamentals | LEGNon balance | revenue growth -4.7% vs 27%; EPS growth -127.5% vs 160%; TTM ROE 77.6% vs -8.7%; gross margin 95.9% vs 56.6%; operating margin -56.2% vs -4.4% — LEGN takes 3 of 5 decided legs, not all of them |
| Valuation | KPTI | Value 65 vs 54 |
| Technicals | LEGN | Price vs 50-day -61.2% vs -3.5%; vs 200-day -93.3% vs -16.1% |
| Risk Resilience | LEGN | Risk Resilience 32 vs 45 |
| Analyst expectations | KPTI | Target upside 1767.8% vs 197.8% |
✓ agrees with the overall verdict · ✕ points the other way. Groups marked “not covered” lack data on one or both of KPTI and LEGN and are excluded from the count.
AIQ Decision Stability
The conclusion is sensitive to small changes. Treat the lead as provisional and watch the flip conditions below.
- The AIQ gap is wide at 13 points. (supports the conclusion holding)
- Only 3 of 6 covered evidence groups agree. (argues the conclusion is provisional)
- The lead has been steady session to session. (supports the conclusion holding)
- The leader is throwing conflicting signals. (argues the conclusion is provisional)
- Analyst targets on the leader are widely dispersed. (argues the conclusion is provisional)
Stability combines the score gap, how broadly the evidence agrees, how steady the lead has been across daily snapshots, the current signal state on both names, and analyst dispersion on KPTI.
How the comparison changed
120 daily snapshots · Jun 22 – Oct 21KPTI lead: Stable — the AIQ differential has held near 13 points over 30 sessions.
- Today
- KPTI +13
- 61 vs 48
- 7 sessions ago
- KPTI +7
- 61 vs 54
- 30 sessions ago
- KPTI +11
- 61 vs 50
- 90 sessions ago
- KPTI +10
- 61 vs 51
The lead has not changed hands in this window.
AIQ Signal Divergence
Only the signals that bear on the head-to-head. A conflicted name is carrying bullish and bearish rules at the same time — the technical evidence is not pointing one way.
2 bullish / 3 bearish / 2 neutral, conflicted
Only KPTI
- Keltner Channel Breakdown — bearish, volatility, short horizon
- RSI Oversold - Potential Bounce — bullish, momentum, short horizon
1 bullish / 2 bearish / 2 neutral, conflicted
No signal that the other name lacks.
Both carry 5 more signals that do not separate them: Bollinger Band Squeeze, Death Cross Active, ATR Expansion - Breakout Mode, Downtrend Structure Active, MACD Bullish Crossover.
KPTI leads the comparison while carrying a conflicted signal state, which is one reason the stability rating is not higher.
Price vs model alignment
Whether the latest session's price move confirms what the model did over the same session, or contradicts it.
Neither the price nor the AIQ Score moved enough in the latest session to confirm or contradict the other (price +28.68%, AIQ 0 points).
Neither the price nor the AIQ Score moved enough in the latest session to confirm or contradict the other (price +1.45%, AIQ 0 points).
What would flip this result
A state, not a forecast. These are the specific, observable changes that would reverse the verdict — not a price prediction.
- 1LEGN closes the Quality gap — currently 48 points behind, the largest single contributor to KPTI's edge.
- 2LEGN's Death Cross Active resolves — a bearish trend rule currently active against it.
- 3KPTI's conflicting signal state resolves bearish — it currently carries 2 bullish and 3 bearish rules at once.
- 4A regime shift changes factor weighting — Quality and Value carry the heaviest weights in the composite, so a rotation toward either would move the result most.
The full evidence
Every number behind the verdict. The leader is called above each group so you are not left to solve it from the table.
Fundamentals
LEGN leads on balance| Metric | KPTI | LEGN |
|---|---|---|
| Revenue growth (YoY) | -4.7% | 27% |
| EPS growth (YoY) | -127.5% | 160% |
| Gross margin | 95.9% | 56.6% |
| Operating margin | -56.2% | -4.4% |
| Return on equity (TTM) | 77.6% | -8.7% |
| Debt to equity | -0.65 | 0.23 |
Performance
LEGN leads 5 of 6 windows| Metric | KPTI | LEGN |
|---|---|---|
| 1 week (5 sessions) | 34.7% | -2.2% |
| 1 month (20 sessions) | -75.7% | 1% |
| 3 months (63 sessions) | -94% | -20.8% |
| 6 months (126 sessions) | -95.6% | -28.2% |
| Year to date | -94.2% | -14.3% |
| 1 year (252 sessions) | -92.8% | -41.7% |
Technicals
LEGN has the stronger structure| Metric | KPTI | LEGN |
|---|---|---|
| RSI (14) | 20.9 | 45 |
| ADX (14) | 62.5 | 14.9 |
| Price vs 50-day | -61.2% | -3.5% |
| Price vs 200-day | -93.3% | -16.1% |
| Volatility (1M, annualized) | 204.1% | 53.5% |
Risk
LEGN is the more resilient| Metric | KPTI | LEGN |
|---|---|---|
| Beta | 0.61 | 0.49 |
| Sharpe ratio | -1.33 | -0.46 |
| Sortino ratio | -1.32 | -0.84 |
| Max drawdown | -97% | -53.1% |
| Current drawdown | -96% | -48.6% |
| Annualized volatility | 124.8% | 75.1% |
| Value at risk (95%) | -10.3% | -6% |
Straight answers
Each answer is regenerated from the current snapshot, not written once and left to age.
Which is better, KPTI or LEGN?
On the Algovestiq AIQ Score, KPTI is the stronger of the two as of Oct 22, 2026, scoring 61 against LEGN's 48. The edge comes from quality and value. LEGN is not without a case — it holds the better momentum profile, which matters more if that is the objective you are optimizing for. This is a systematic score, not a recommendation: it ranks the two on the same evidence, it does not know your holding period or tax position.
Is KPTI or LEGN the better buy right now?
KPTI carries the stronger systematic profile as of Oct 22, 2026, and the comparison is rated Fragile — 3 of 6 covered evidence groups agree. A Fragile rating means the conclusion is sensitive: only 3 of 6 covered evidence groups agree. Treat the lead as provisional.
Why does the AIQ Score favor KPTI over LEGN?
The composite weights Quality, Value, Momentum and Risk Resilience. KPTI leads Quality by 48 points; LEGN leads Momentum by 13 points; LEGN leads Risk Resilience by 13 points. Where the two split, the factor with the larger weight carries the result.
Which has more analyst upside, KPTI or LEGN?
Analyst price targets imply +1767.8% upside for KPTI and +197.8% for LEGN, so the Street currently favors KPTI. The model and the Street agree here, which is a broader base of evidence than either alone. Analyst targets are expectations, not predictions, and dispersion matters as much as the midpoint.
Which is better value, KPTI or LEGN?
KPTI is the better-valued of the two on the peer-relative Value factor. KPTI on the peer-relative Value factor, by 11 points. The Value factor reads valuation relative to sector peers and to the company's own fundamental quality, so it is not the same as simply having the lower multiple.
Which has stronger growth, KPTI or LEGN?
LEGN on combined revenue and EPS growth. Growth here is measured on reported revenue and earnings, not on forward estimates — it describes what the businesses have delivered, not what the Street expects next.
Which has stronger momentum, KPTI or LEGN?
LEGN on the Momentum factor, by 13 points. Momentum is one of the four weighted factors in the AIQ composite. It has documented persistence over three- to twelve-month horizons, which makes it a timing input rather than a reason to hold something indefinitely.
Which is riskier, KPTI or LEGN?
LEGN is the more resilient of the two, so the other name carries the higher downside risk. LEGN on Risk Resilience, by 13 points. Risk Resilience is a weighted factor in the composite; position sizing usually responds to it more usefully than the buy/avoid decision does.
Is KPTI more profitable than LEGN?
The profitability evidence is mixed: gross margin 95.9% vs 56.6%; operating margin -56.2% vs -4.4%; ttm roe 77.6% vs -8.7%. KPTI leads on two measures and LEGN on one measure, and there is no single profitability composite that resolves the split — which of the two reads as "more profitable" depends on whether you weight pricing power or operating leverage.
Is KPTI's lead over LEGN getting stronger or weaker?
KPTI lead: Stable — the AIQ differential has held near 13 points over 30 sessions. This is measured from 120 daily comparison snapshots between 2026-06-22 and 2026-10-21. The lead has not changed hands in that window.
What would change the KPTI vs LEGN verdict?
The result is a state, not a forecast, so it changes when the underlying evidence changes. Concretely: LEGN closes the Quality gap — currently 48 points behind, the largest single contributor to KPTI's edge; LEGN's Death Cross Active resolves — a bearish trend rule currently active against it; KPTI's conflicting signal state resolves bearish — it currently carries 2 bullish and 3 bearish rules at once; a regime shift changes factor weighting — Quality and Value carry the heaviest weights in the composite, so a rotation toward either would move the result most.
What do the current signals say about KPTI and LEGN?
KPTI: 2 bullish / 3 bearish / 2 neutral, conflicted. LEGN: 1 bullish / 2 bearish / 2 neutral, conflicted. A conflicted state means bullish and bearish rules are active on the same name at once — the technical evidence is not pointing one way, and a decision taken on it carries more timing risk. The most decision-relevant rule on KPTI is Death Cross Active (bearish, long horizon). On LEGN it is Death Cross Active (bearish, long horizon).
Compare KPTI and LEGN with others
Continue your research
This page answers which of the two. These answer the questions on either side of it.
How this comparison is scored
The Algovestiq AIQ Score composites four factors — Quality, Value, Momentum and Risk, each carrying a fixed weight. Sentiment is reported separately as SentimentPulse and is not folded into the composite. Scores refresh every trading day, and this page regenerates from the latest snapshot rather than being written once.
The verdict names a leader, states how broadly six independent evidence groups agree, and rates how durable that conclusion is given the score gap, its recent trajectory and the current signal state on both names.
How to use side-by-side comparison →This comparison is informational and educational, not investment advice. AIQ scores update daily; re-check after earnings, guidance or macro data that materially changes either name’s factor profile.